ベンザルコニウムテンプレートメソ構造のシリカ抗菌剤の単体熱水合成
Viktor Dubovoy1, Anjani Ganti2, Tao Zhang2
1Department of Chemistry and Chemical Biology , Rutgers, The State University of New Jersey , Piscataway , New Jersey 08854 , United States.
Journal of the American Chemical Society
|September 28, 2018
まとめ
新しいシリカ微粒子は,抗菌薬としてベンザルコニウム塩化物 (BAC) を供給します. これらの材料はpHに反応する薬の放出を示し,細菌の生存能力を効果的に低下させ,消毒剤の適用を助けます.
科学分野:
- 材料科学
- ナノテクノロジー
- 医薬品科学
背景:
- メソポラス・シリカ微粒子は 薬の投与を制御する可能性を秘めています
- ベンザルコニウム塩化物 (BAC) は,広く使用されている抗菌剤です.
- 抗菌剤の有効な投与システム (DDS) の開発は,医薬品と食品産業にとって極めて重要です.
研究 の 目的:
- 抗菌薬の投与のための新型のメソポラスシリカ微粒子を合成し,特徴づけること.
- 薬物の負荷能力,毛穴構造,シリカ微粒からのBACの放出運動を調査する.
- Staphylococcus aureusとSalmonella entericaに対するBACを含むシリカ微粒子の抗菌効果を評価する.
主な方法:
- メソポラスシリカ微粒子の合成と特徴付け
- ベンザルコニウム塩化物 (BAC) をシリカマトリックスに注入する.
- 小角X線 difraktion (SAXRD) とBarrett-Joyner-Halenda (BJH) 分析により,毛穴の構造を決定する.
- 異なるpH値でのインビトロ薬剤放出試験
- 細菌の生存能力の低下を決定する微生物学的検査
主要な成果:
- 高BAC負荷 (0.56g/gSiO2),高表面積 (1500m2/g) と18 Åの孔のチャンネルを持つ合成したシリカ微粒子.
- 表面の修正なしに,pHに対応した,制御されたBACの放出が実証されている.
- Korsmeyer- Peppasモデル分析は,酸性対中性pHで明確な放出メカニズムを明らかにした.
- Staphylococcus aureusとSalmonella entericaの生存能力が時間によって著しく低下することが観察されました.
結論:
- 新しいメソポーズシリカ微粒子は,pH対応の放出でBACに対して有効なDDSである.
- この材料は,グラム陽性およびグラム陰性細菌に対する強力な抗菌作用を示しています.
- 薬剤や食品の消毒剤としてBACの使用を拡大することを支持しています.
関連する概念動画
DNA as a Genetic Template
27.9K
Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
27.9K
DNA as a Genetic Template
9.5K
9.5K
Dehydration Synthesis
149.8K
Overview
Dehydration synthesis (also called a condensation reaction) is the chemical process in which two molecules covalently link together to form a new molecule, along with the release of a water molecule. Many physiologically important compounds form by dehydration synthesis reactions, such as complex carbohydrates, proteins, DNA, and RNA.
Synthesis of carbohydrates
Sugar molecules are covalently linked together by dehydration synthesis. During the reaction, the hydroxyl (-OH) group from...
Dehydration synthesis (also called a condensation reaction) is the chemical process in which two molecules covalently link together to form a new molecule, along with the release of a water molecule. Many physiologically important compounds form by dehydration synthesis reactions, such as complex carbohydrates, proteins, DNA, and RNA.
Synthesis of carbohydrates
Sugar molecules are covalently linked together by dehydration synthesis. During the reaction, the hydroxyl (-OH) group from...
149.8K
Synthesis and Decomposition Reactions
38.2K
Synthesis and decomposition are two types of redox reactions. Synthesis means to make something, whereas decomposition means to break something. The reactions are accompanied by chemical and energy changes.
38.2K
Silica Gel Column Chromatography: Overview
3.6K
Silica gel column chromatography is a technique for separating compounds using a column packed with silica gel as the stationary phase. This method relies on differences in the polarity of compounds. Based on their polarities, compounds move between the stationary phase (silica gel) and the mobile phase (the solvent), forming discrete bands in the column.
Polar components tend to bind strongly to the silica gel, causing them to move slowly through the column. In contrast, nonpolar compounds...
Polar components tend to bind strongly to the silica gel, causing them to move slowly through the column. In contrast, nonpolar compounds...
3.6K
Lagging Strand Synthesis
61.4K
During replication, the complementary strands in double-stranded DNA are synthesized at different rates. Replication first begins on the leading strand. Replication starts later, occurs more slowly, and proceeds discontinuously on the lagging strand.
There are several major differences between synthesis of the leading strand and synthesis of the lagging strand. 1) Leading strand synthesis happens in the direction of replication fork opening, whereas lagging strand synthesis happens in the...
There are several major differences between synthesis of the leading strand and synthesis of the lagging strand. 1) Leading strand synthesis happens in the direction of replication fork opening, whereas lagging strand synthesis happens in the...
61.4K


![Microwave-assisted One-pot Synthesis of N-succinimidyl-4-[18F]fluorobenzoate [18F]SFB](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F2755.jpg&w=3840&q=50)