(-) ノドリスポル酸Cの12段階の非対称合成
Nicole A Godfrey1, Devon J Schatz1, Sergey V Pronin1
1Department of Chemistry , University of California, Irvine , Irvine , California 92697-2025 , United States.
Journal of the American Chemical Society
|September 29, 2018
まとめ
この研究は, (-) - ノドリスポル酸Cの簡潔でエナンチオセレクティブな合成を示しています.効率的な12段階の経路は,インドロテルペノイド標的の主要なポリサイクリングとコンバージェントアセンブリを使用しています.
科学分野:
- 有機化学
- 自然製品合成
背景:
- (-) ノドリスポル酸Cは,潜在的生物学的活性を持つ複雑なインドルテルペノイドである.
- このような複雑な天然製品へのアクセスには 効率的な合成経路が不可欠です
研究 の 目的:
- (-) - ノドリスポリック酸Cの短時間およびエナチオセレクティブの合成を開発する.
- 複雑な分子構築のための新しい合成方法の有用性を実証する.
主な方法:
- ダイアステロセレクティブポリサイクライゼーションを用いたエナンチオセレクティブ合成.
- 挑戦的なインドル分子の収束
- 商業的に利用可能な材料を用いて 効率的なアプローチをとる.
主要な成果:
- (-) ノドリスポル酸Cの12段階合成を達成した.
- 重要なポリサイクライゼーションのステップで高いダイアステレオ選択性を示した.
- 複雑なターペノイドの核とインデノピランの断片を 組み立てました
結論:
- 開発された合成経路は効率的でエナチオセレクティブです.
- この方法論は,他の複雑なインドルテルペノイドの合成に適用できます.
- この研究は, (-) ノドリスポル酸Cへのアクセスに有益な経路を提供する.
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