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Updated: Feb 4, 2026

Immunohistochemical Detection of 5-Methylcytosine and 5-Hydroxymethylcytosine in Developing and Postmitotic Mouse Retina
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Immunohistochemical Detection of 5-Methylcytosine and 5-Hydroxymethylcytosine in Developing and Postmitotic Mouse Retina

Published on: August 29, 2018

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シングルベース解像度で 5-ヒドロキシメチルシトシンのナノスケール解析

Hu Zeng1, Bo He2, Bo Xia1

  • 1State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences , Peking University , Beijing 100871 , China.

Journal of the American Chemical Society
|October 3, 2018
PubMed
まとめ

この研究では,小さなDNAサンプルでも,基底解像度で全ゲノムにわたる5-ヒドロキシメチルシトシン (5hmC) を検出するための新しい,ビスルフィットのない方法であるhmC-CATCHを導入しています. この技術は,幹細胞と細胞フリーDNAで費用対効果の高いヒドロキシメチローム分析を可能にします.

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