抗体とTLR7アゴニストは,SHIVに感染したサルにおけるウイルスリバウンドを遅らせます
Erica N Borducchi1, Jinyan Liu1, Joseph P Nkolola1
1Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Nature
|October 5, 2018
まとめ
この研究では,抗レトロウイルス治療 (ART) 中のHIV-1ウイルスの貯蔵体への標的を調査した. 広く中和する抗体 (bNAbs) と免疫刺激剤を組み合わせることで,サルにおけるウイルスのリバウンドが遅延し,HIV治療の潜在的な戦略を示唆した.
科学分野:
- 免疫学
- ウイルス学
- 感染症
背景:
- 潜伏するHIV-1ウイルスの貯蔵庫は 治癒の大きな障害です
- 広く中和する抗体 (bNAbs) は抗ウイルス活性を示すが,ART中に貯蔵体を標的とするその役割は不明である.
研究 の 目的:
- 抗レトロウイルス治療 (ART) の際にbNAbsがHIV-1貯蔵体を標的とするかどうかを調査する.
- bNAbと免疫刺激剤の組み合わせを評価する.
主な方法:
- SHIV- SF162P3に感染したレサス猿のART中にbNAb PGT121およびTLR7アゴニストベサトリモド (GS-9620) を投与する.
- ARTを中止した後のウイルスリバウンド評価
- 動物のサブセットでの養子移植とCD8枯渇の研究
主要な成果:
- ART中にPGT121とGS-9620を併用すると,ART停止後のウイルスリバウンドが遅れた.
- リバウンド,アドプティブ・トランスファー,CD8枯渇の研究ではウイルスが検出されなかった.
- これはウイルスの貯蔵庫が 標的だったことを示しています
結論:
- bNAbsと先天的な免疫刺激を組み合わせることは,潜伏するHIV-1貯蔵体を標的とする有効な戦略である可能性があります.
- このアプローチはHIV-1感染症の 機能的な治療法を開発する可能性を秘めています
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