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関連する概念動画

Protein Networks02:26

Protein Networks

4.6K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.6K
Protein Networks02:26

Protein Networks

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2.9K
Network Covalent Solids02:18

Network Covalent Solids

16.2K
Network covalent solids contain a three-dimensional network of covalently bonded atoms as found in the crystal structures of nonmetals like diamond, graphite, silicon, and some covalent compounds, such as silicon dioxide (sand) and silicon carbide (carborundum, the abrasive on sandpaper). Many minerals have networks of covalent bonds.
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...
16.2K
Protein Complex Assembly02:41

Protein Complex Assembly

16.8K
Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
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Reversible and Irreversible Processes01:14

Reversible and Irreversible Processes

5.8K
The thermodynamic processes can be classified into reversible and irreversible processes. The processes that can be restored to their initial state are called reversible processes. It is only possible if the process is in quasi-static equilibrium, i.e., it takes place in infinitesimally small steps, and the system remains at equilibrium However, these are ideal processes and do not occur naturally. An ideal system undergoing a reversible process is always in thermodynamic equilibrium within...
5.8K
Diode: Reverse bias01:14

Diode: Reverse bias

1.9K
A diode is reverse-biased when the positive terminal of an external voltage source is connected to the n-type material and the negative terminal to the p-type material. This configuration opposes the natural direction of current flow through the diode, effectively increasing the width of the depletion region and the barrier potential. The reverse bias condition produces a minimal leakage current, primarily due to minority charge carriers. This leakage becomes significant when the reverse...
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Assembling Molecular Shuttles Powered by Reversibly Attached Kinesins
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超構造ネットワークの可逆自己組み立て

Ronit Freeman1, Ming Han2, Zaida Álvarez1

  • 1Simpson Querrey Institute, Northwestern University, Chicago, IL 60611, USA.

Science (New York, N.Y.)
|October 6, 2018
PubMed
まとめ

科学者はペプチド-DNA結合を用いて ダイナミックな水素ゲルを作りました これらのスマート素材は 分子信号と 変化する電荷密度に反応し 柔らかいロボット工学と 再生医療に 新たな可能性を秘めています

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Characterization of pH-Dependent Reversible Self-Assembly of Amyloid Beta 1-40-Coated Gold Colloids
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Assembly, Loading, and Alignment of an Analytical Ultracentrifuge Sample Cell
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Assembly, Loading, and Alignment of an Analytical Ultracentrifuge Sample Cell

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科学分野:

  • 材料科学
  • バイオテクノロジー
  • 超分子化学

背景:

  • 自然は,ダイナミックな柔らかい物質の組織化のために,可逆的非共性相互作用を利用する.
  • 合成材料は このダイナミックな組み立て解き能力を 複製するのに苦労します

研究 の 目的:

  • 合成ヒドロゲルを設計し 復元可能な自己組み立てと分解機能を備える
  • これらのヒドロゲルの ダイナミックな行動を駆動する 分子機構を調査する

主な方法:

  • ペプチド-DNA結合体とペプチドからヒドロゲルを製造する.
  • ハイドロゲル上部構造の形成と分解の実験的特徴付け
  • 構造と性質の関係を理解するための分子ダイナミクスシミュレーション

主要な成果:

  • 交絡した繊維の逆転可能な上部構造を形成した.
  • 分子結合や電荷密度の変化が 解体を引き起こした
  • 反応には,非共性相互作用によって引き起こされる大規模な分子再分配が必要でした.
  • 神経細胞のフェノタイプにおける可逆的な変化と相関する可逆的な構造変化.

結論:

  • 調節可能な自己組み立てのダイナミックヒドロゲルの新しいクラスを示した.
  • リバーシブルな構造における 超分子結合エネルギーの重要な役割を強調した.
  • 反応性のある生体材料と細胞培養プラットフォームの潜在的応用を示した.