代謝状態によって支配される内皮からアディポサイトまでの細胞外膀軸

Clair Crewe¹, Nolwenn Joffin¹, Joseph M Rutkowski¹

¹Touchstone Diabetes Center, Department of Internal Medicine, the University of Texas Southwestern Medical Center, Dallas, TX, USA.

Cell

|October 9, 2018

まとめ

脂肪組織細胞は細胞外小胞 (EVs) を通じて伝達する. 内皮細胞は,カベオリン1 (cav1) を含んだEVを脂肪細胞に転送し,それらは相互反応し,新しい細胞間信号伝達経路を明らかにする.

科学分野:

細胞生物学
メタボリズム
生理学

背景:

細胞外膀 (EV) は細胞間通信を媒介する.
カヴェオリン1 (cav1) は細胞のプロセスに作用する.
脂肪組織 (AT) には複雑な細胞間相互作用がある.

研究の目的:

脂肪組織における脂肪細胞と内皮細胞 (ECs) の間のEV媒介信号の調査.
この細胞間通信における cav1の役割を理解するために
この信号の生理学的調節を調べるため

主な方法:

細胞間EV転送の研究のための新しいマウスモデルの生成.
脂肪細胞とEC間のEV交換のインビボ分析
CAV1タンパク質の濃度とEV含有量の評価

主要な成果:

アディポサイトとECは,体内で双方向のEV交換を行います.
ECは,cav1を含むEVをアディポサイトに転送し,アディポサイトはEVと相互反応する.
EVはプラズマ成分の移転を容易にし,信号伝達経路を調節する.
このEV通信は栄養状態 (断食/再給食) と肥満によって制御されます.

結論:

脂肪組織内の脂肪細胞とECの間には,EV経由の細胞間通信の新しいメカニズムが存在する.
この経路は,cav1および他のバイオ分子が移転し,細胞のシグナル伝達と栄養素の交換に影響を与えます.
脂肪組織におけるEV媒介信号は,生理的状態によって動的に調節され,組織機能と全身の栄養素反応に影響を与えます.

キーワード:

脂肪組織カベオリン 1 内皮細胞エクソソーム細胞外ベシクル断食するグルカゴンメタボリズム肥満

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