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Updated: Feb 4, 2026

Author Spotlight: Integrating BRET-Based Assays and Rare Mutation Analysis to Decipher RAF Kinase Regulation in Live Cells
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14-3-3のタンパク質間相互作用における多価性の熱力学モデル

Loes M Stevers1, Pim J de Vink1, Christian Ottmann1

  • 1Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems , Technische Universiteit Eindhoven , P.O. Box 513, Eindhoven 5600 MB , The Netherlands.

Journal of the American Chemical Society
|October 10, 2018
PubMed
まとめ

多価タンパク質相互作用 (PPI) の熱力学モデルを開発し,複数の結合部位が結合親和性にどのように影響するかを明らかにしました この研究は,複雑な疾患における薬剤発見のためのPPI安定化に関する洞察を提供します.

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