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Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
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細胞アイデンティティスイッチは,残留BCCがヘッジホッグ経路の阻害を生き残ることを可能にします

Brian Biehs1, Gerrit J P Dijkgraaf1, Robert Piskol2

  • 1Department of Molecular Oncology, Genentech, San Francisco, CA, USA.

Nature
|October 10, 2018
PubMed
まとめ

ヴィスモデジブのようなヘッジホッグ経路阻害剤は,再発する基礎細胞癌 (BCC) の残留腫瘍を残す可能性があります. これらの残留BCCは 幹細胞のようなアイデンティティに切り替わり 治療を回避します

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