脊髄 損傷 後 の 呼吸 を 維持 する 頸部 の 刺激 ニューロン
Kajana Satkunendrarajah1, Spyridon K Karadimas2, Alex M Laliberte3
1Krembil Research Institute, University Health Network, Toronto, Ontario, Canada. kajanasatkune@gmail.com.
Nature
|October 12, 2018
まとめ
脊髄損傷後の呼吸を回復します 脊髄損傷後の呼吸を回復します これらのニューロンを刺激することで 中枢神経系の損傷後の 呼吸器の回復と機能が促進されます
科学分野:
- 神経科学
- 呼吸器の生理学
- トラウマ研究
背景:
- 呼吸機能障害は 頸椎脊髄損傷による 主な死因です
- 助呼吸器はしばしば必要であり,呼吸回復戦略の必要性を強調しています.
- 頸部内ニューロンはフレーニックの運動出力と膜機能を調節する.
研究 の 目的:
- 呼吸における中刺激内ニューロンの役割を調査する.
- 脊髄損傷後の呼吸維持と回復に不可欠であるかどうかを判断する.
- 怪我後の呼吸を回復するための戦略として 薬剤遺伝的刺激を研究する.
主な方法:
- 薬剤遺伝学と呼吸器生理学的測定を用いた.
- 脊髄損傷のモデルを研究しました
- 頸部刺激性内ニューロンを刺激する効果を調べた.
主要な成果:
- 中部頸部刺激性内ニューロンは,非トラウマ性頸部脊髄損傷モデルにおける呼吸に不可欠である.
- これらの内部ニューロンは 脊髄外傷後の呼吸器の回復に不可欠です
- これらの内部ニューロンの刺激により,怪我をしていない動物のインスピレーション幅が増加し,怪我の直後に機能が回復しました.
結論:
- 脊髄損傷後の呼吸の維持と回復に不可欠である.
- 中枢神経系外傷後の呼吸機能の回復のための潜在的な戦略を提示しています.
- トラウマ後の呼吸機能障害の治療には 有望なアプローチです
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