プロバイオティクスのバシルスによる病原体除去 信号干渉
Pipat Piewngam1,2, Yue Zheng1, Thuan H Nguyen1
1Pathogen Molecular Genetics Section, Laboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Nature
|October 12, 2018
まとめ
プロバイオティクスのバチルスはフェンギシン・リポペプチドを介して,クオラムセンシングを遮断することで,Staphylococcus aureusを排除します. このプロバイオティクスのメカニズムは 病原体の植民を減らし,脱植民と感染と戦うための新しい戦略を提供します.
科学分野:
- 微生物学
- 人間 の 健康
- プロバイオティクスの栄養
背景:
- プロバイオティクスの食品は 病原体の植民を減らすことで 人間の健康を向上させると主張されています
- これらの健康上の利点の 背後にある正確なメカニズムは 完全に理解されていません
- 病原体の感受性を減らすことは,感染症の研究の重要な分野です.
研究 の 目的:
- プロバイオティクスのバクテリアが病原体植民を減少させる 分子機構を調査する.
- プロバイオティクスのバチルス菌が 黄金球菌の植民を防ぐ効果を 調べるため
- Staphylococcus aureus感染と戦うための新しい戦略を探求する.
主な方法:
- タイの農村部で プロバイオティクスのバチロスを摂取する
- バチルス・リポペプチドの分析,特にフェンギシン.
- Staphylococcus aureusのクオラムセンシング経路の調査
主要な成果:
- プロバイオティクスのバチルスの摂取は 黄色のスタフィロコクスの植民を完全に防ぐことができました
- フェンジシンは,S. aureusを排除する活性化合物として特定されました.
- フェンジシンはバクテリアの伝達システムであるS. aureus quorum sensingを阻害する.
- このメカニズムは,病原体のシグナル伝達を遮断することによって,プロバイオティクスの細菌干渉を示しています.
結論:
- プロバイオティクスの栄養,特にバチルスの摂取は,Staphylococcus aureusの植民を効果的に減少させます.
- フェンジシンは,S. aureusのクオラムセンシングを妨害することで,プロバイオティクスの有効性において重要な役割を果たします.
- 病原体のシグナル伝達システムを遮断することは 脱植民地化と感染制御のための有望な道を提供します
- この研究は 感染症のリスクを減らすために プロバイオティクスの利点の 分子基盤を提供します
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