Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Genomics02:02

Genomics

40.7K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
40.7K
Transduction01:16

Transduction

1.7K
Among the three main modes of HGT—transformation, conjugation, and transduction—transduction is unique in that it is mediated by bacteriophages, or bacterial viruses.Transduction occurs in two ways. Generalized transduction occurs during the lytic cycle of a bacteriophage infection. In this process, bacteriophages infect bacterial cells, replicate within them, and ultimately cause cell lysis, releasing newly assembled virions. Occasionally, random fragments of the bacterial genome...
1.7K
Lateralization01:28

Lateralization

1.0K
Brain lateralization refers to the division of mental processes and functions between the two hemispheres of the brain, a phenomenon that optimizes neural efficiency and underpins complex abilities in humans. This specialization allows each hemisphere to perform tasks where it has a comparative advantage, facilitating more refined cognitive capabilities across different domains.
1.0K
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

37.2K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
37.2K
Signal Transduction: Overview01:26

Signal Transduction: Overview

11.5K
Cells respond to many types of information, often through receptor proteins positioned on the membrane. They respond to chemical signals, such as hormones, neurotransmitters, and other signaling molecules, initiating a series of molecular reactions to produce an appropriate response. This is called signal transduction. Cells also coordinate different responses elicited by the same signaling molecule via mediators, allowing molecular cross-talk.
Typically, signal transduction involves three...
11.5K
Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

9.1K
While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
9.1K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Revisiting the life cycle of temperate phages.

Nature reviews. Microbiology·2026
Same author

Accelerating scientific discovery with Co-Scientist.

Nature·2026
Same author

Immune-deficient bacteria serve as gateways to genetic exchange and microbial evolution.

Nature communications·2026
Same author

Evaluation of antimicrobial resistance governance across 193 countries to inform the 2026 Global Action Plan update.

Nature medicine·2026
Same author

Immune-adaptive pathogen variation reveals targetable mediators of gram-positive bacterial killing in macrophages.

Science advances·2026
Same author

Bacterial defense systems and host ecology drive the evolution of intra-species lineages.

Cell reports·2026

関連する実験動画

Updated: Feb 4, 2026

Isolation and Genome Analysis of Single Virions using 'Single Virus Genomics'
08:31

Isolation and Genome Analysis of Single Virions using 'Single Virus Genomics'

Published on: May 26, 2013

11.5K

横転転移によるゲノムハイパーモビリティ

John Chen1, Nuria Quiles-Puchalt2, Yin Ning Chiang3

  • 1Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Science Drive 2, Singapore. miccjy@nus.edu.sg joser.penades@glasgow.ac.uk.

Science (New York, N.Y.)
|October 13, 2018
PubMed
まとめ

バクテリアの適応は 遺伝子変換によって引き起こされます Staphylococcus aureusのファージは,遺伝子転送を促進するために大きなゲノム領域を包装する新しい横向転移経路を使用します.

さらに関連する動画

Transient Transduction of the Strobilated Forms of Echinococcus granulosus
13:25

Transient Transduction of the Strobilated Forms of Echinococcus granulosus

Published on: September 16, 2022

3.6K
Digital Droplet PCR Method for the Quantification of AAV Transduction Efficiency in Murine Retina
09:50

Digital Droplet PCR Method for the Quantification of AAV Transduction Efficiency in Murine Retina

Published on: December 25, 2021

5.2K

関連する実験動画

Last Updated: Feb 4, 2026

Isolation and Genome Analysis of Single Virions using 'Single Virus Genomics'
08:31

Isolation and Genome Analysis of Single Virions using 'Single Virus Genomics'

Published on: May 26, 2013

11.5K
Transient Transduction of the Strobilated Forms of Echinococcus granulosus
13:25

Transient Transduction of the Strobilated Forms of Echinococcus granulosus

Published on: September 16, 2022

3.6K
Digital Droplet PCR Method for the Quantification of AAV Transduction Efficiency in Murine Retina
09:50

Digital Droplet PCR Method for the Quantification of AAV Transduction Efficiency in Murine Retina

Published on: December 25, 2021

5.2K

科学分野:

  • 微生物学
  • 進化生物学
  • 遺伝学

背景:

  • バクテリオファージによる遺伝変換は,細菌の進化と適応の鍵となるメカニズムである.
  • 温和型バクテリオファージは プロファージとして宿主ゲノムに統合される.
  • 標準的なバクテリオファージのライフサイクルには,ファージDNAの切除,複製,包装が含まれています.

研究 の 目的:

  • Staphylococcus aureus の温帯細菌菌が利用する変換メカニズムを調査する.
  • 前述した経路とは異なる新しい変換形態を特徴づける.

主な方法:

  • Staphylococcus aureusのプロファージのリティックプログラム解析
  • 統合プロファージ内のDNA包装の開始とプロセスの調査.
  • S. aureusの大きなゲノムセグメントの高周波包装

主要な成果:

  • スタフィロコックスのプロファージは 横行伝導と呼ばれるユニークな経路を利用します
  • プロファージは溶解周期の後期に消去され,DNA包装を局所的に開始する.
  • 大規模なゲノム領域 (数百基) のS. aureusは高周波でファグヘッドに詰め込まれています.
  • 局所複製は複数のプロファージゲノムを生成し,横向変換粒子を発生させます.

結論:

  • 横向トランスデュークションは,S. aureus染色体の一部を遺伝子転送のための超移動領域に変換します.
  • このメカニズムは 細菌の適応における 重要な進化的力を表しています
  • この発見は,バクテリオファージによって媒介される 横断的な遺伝子転送の新しい方法を明らかにした.