デンドリット細胞におけるDNGR-1は,中性粒子の増殖を抑制することによって,組織損傷を抑制する
Carlos Del Fresno1, Paula Saz-Leal2, Michel Enamorado2
1Immunobiology Laboratory, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain. dsancho@cnic.es cdelfresno@cnic.es.
Science (New York, N.Y.)
|October 20, 2018
まとめ
デンドリット細胞の自然キラーレクチン群受容体-1 (DNGR-1) は,損傷後の炎症反応と組織損傷を抑制する. DNGR-1欠乏症は,中性愛性の増加によって炎と感染症の病態を悪化させる.
科学分野:
- 免疫学
- 細胞生物学
- 感染症
背景:
- ホストの損傷は 組織損傷を制限するフィードバックメカニズムを活性化します
- 従来の1型 dendritic細胞 (cDC1s) は,DNGR-1 (Clec9aによってエンコード) を発現し,組織損傷を感知し,CD8+ T細胞へのクロスプレゼンテーションを促進します.
研究 の 目的:
- 不妊および感染性組織損傷に対する炎症反応の調節におけるDNGR-1の役割を調査する.
- DNGR-1が宿主有害な炎症に影響を与えるメカニズムを解明する.
主な方法:
- マウスモデルを用いて,不妊の損傷 (ケルーリン誘発性臓炎) と感染症の損傷 (Candida albicansの全身感染) を調べました.
- 野生型およびDNGR-1欠乏したマウスの病理学,免疫細胞浸透 (中性愛),およびサイトカイン生成 (MIP-2/Cxcl2) を評価した.
- SHP-1信号経路の関与を調査した
主要な成果:
- DNGR-1欠乏症は死板炎とCandida albicans感染症の病態を悪化させた.
- DNGR-1欠乏症のマウスでは,B細胞とT細胞にかかわらず,中性愛性の増加が観察されました.
- DNGR- 1の関与は,カンジダ感染中にSHP- 1を活性化し,中性粒子の増殖を抑制したcDC1sによるMIP- 2の生成を阻害した.
結論:
- DNGR-1は,先天的な免疫反応と組織損傷の重要なレギュレータとして作用します.
- cDC1sにおけるDNGR-1シグナリングは中性粒子の増殖を抑制し,疾患耐性を促進し,それによって免疫病理を制御する.
関連する概念動画
02:27Limiting Reactant
70.1K
The relative amounts of reactants and products represented in a balanced chemical equation are often referred to as stoichiometric amounts. However, in reality, the reactants are not always present in the stoichiometric amounts indicated by the balanced equation.
70.1K
01:23Neurons: The Cell Body and the Dendrites
7.1K
A typical nerve cell comprises three main components: the cell body, dendrites, and the axon. The cell body, also known as the soma or perikaryon, serves as the central biosynthetic hub housing a nucleus surrounded by cytoplasm containing organelles commonly found in most cells. Notably, Nissl bodies, clusters of the rough endoplasmic reticulum and free ribosomes responsible for protein synthesis, are distinctive features of the neuronal cell body. As neurons age, aggregates of a brown pigment...
7.1K
01:29The Number e as a Limit
87
The number e is a fundamental constant in calculus, playing a central role in describing continuous change, particularly exponential growth. It is most naturally defined through its relationship with the natural logarithm, which is the inverse of the exponential function with base e. This relationship allows e to be characterized using basic principles of differentiation rather than as an arbitrary numerical constant.A key property of the natural logarithm function, ln x, is that its derivative...
87
02:36DNA Damage Can Stall the Cell Cycle
3.2K
In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
3.2K
02:36DNA Damage can Stall the Cell Cycle
10.1K
In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
10.1K
02:01Plant Cells and Tissues
65.7K
Plant tissues are collections of similar cells performing related functions. Different plant tissues will have their own specialized roles and can be combined with other tissues to form organs such as flowers, fruit, stem, and leaves. Two major types of plant tissue include meristematic and permanent tissue.
65.7K