ダイナミック・アンド・レスポンシブ・DNAのようなポリマー

Sudheendran Mavila¹, Brady T Worrell¹, Heidi R Culver¹

¹Department of Chemical and Biological Engineering , University of Colorado-Boulder , Boulder , Colorado 80309 , United States.

Journal of the American Chemical Society

|October 24, 2018

まとめ

研究者らは,リング開封ポリメリゼーション (ROP) のための新しいチオラクトンモノマーを合成した. これらのポリマーは,チオール-チオエステル交換によって動的な再配置を可能にし,制御されたポリマー合成を可能にします.

科学分野:

ポリマー化学
有機合成
材料科学

背景:

核酸類は様々な用途で不可欠である.
リング開封ポリメリゼーション (ROP) は,多用途のポリメリゼーション技術である.
ポリマーの合成は依然として大きな課題です

研究の目的:

天然の核酸を真似した新型のチオラクトン単体を作る.
これらのモノメアのリング開封ポリメリゼーション (ROP) を調査する.
制御された合成のために生成されたポリマーのダイナミックな再配置能力を探求する.

主な方法:

ニュクレオシドを模倣するように設計されたチオラクトン単体合成.
これらのモノマーを用いた強固なリング開封ポリメリゼーション (ROP) の実行.
ポリマー分解とポリマー凝結を含むチオール-チオエステル交換によるダイナミックなポリマー再配置の実証.

主要な成果:

ティオラクトン単体合成に成功
ロバスト・リング・オープニング・ポリメリゼーション (ROP) で,チオエステル機能群を持つポリマーが得られる.
異なる特性を持つポリマーのデポリメリゼーションと融合を含む,ダイナミックなポリマーの再配置の実現可能性が実証されています.

結論:

開発されたチオラクトンモノマーとROPプロセスは,ダイナミックなポリマーの作成を可能にします.
チオール-チオエステル交換は,ポリマーの再配置と制御された合成のためのメカニズムを提供します.
この研究は,配列制御されたポリマーの常時合成を可能にするプラットフォームの基礎を築いています.

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