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Updated: Sep 2, 2026

Quantification of Intracellular Growth Inside Macrophages is a Fast and Reliable Method for Assessing the Virulence of Leishmania Parasites
10:01

Quantification of Intracellular Growth Inside Macrophages is a Fast and Reliable Method for Assessing the Virulence of Leishmania Parasites

Published on: March 16, 2018

コンプリメントの第3の成分 (C3) は,ライシュマニアメジャー菌の細胞内生存に責任があります

D M Mosser, P J Edelson

    Nature
    |May 3, 1987
    PubMed
    まとめ

    コンプリメント固定は,レイスマニアの寄生虫が免疫反応を回避するのを助けます. コンプリメントコーティングの寄生虫は,宿主細胞を減少させることで,マクロファージ内でよりうまく生き残ります.

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    Cell-mediated Immune Responses01:40

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    Overview
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    Defense Against Bacterial Pathogens

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    Complement System

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    Pathogen colonization of host tissues is a critical step in the development of infectious diseases. Various pathogenic microorganisms, including bacteria, fungi, viruses, and protozoa, have evolved complex strategies to attach to, invade, and persist within host environments. These mechanisms enable pathogens to establish infections, evade immune responses, and resist antimicrobial treatments.Attachment to Host CellsIn bacteria, colonization typically begins with adherence to host epithelial...
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    Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...