心臓病症候群の再発

Faiez Zannad^1,2, Patrick Rossignol^1,2,3

¹Universite de Lorraine, Inserm, Centre d'Investigations Cliniques-1433 and Inserm U1116, CHRU Nancy, France (F.Z., P.R.).

Circulation

|October 26, 2018

まとめ

心臓や腎臓の疾患の共通経路である線維症は,心臓・腎臓症候群の主な原因である可能性があります. 繊維症をターゲットにすることでこれらの相互に関連した疾患に対する新しい治療法が生まれるかもしれません

科学分野:

心臓病科
腎臓科
病理生理学

背景:

心臓神経症候群は5つのサブタイプに分類されるが,この記述的アプローチには病理学的洞察と臨床的影響が欠けている.
既存の分類は,心臓と腎臓機能障害の複雑な相互作用を完全に説明できません.
最近の研究では心臓腎臓症候群の病理生理学的経路が共通していることが示されています

研究の目的:

心臓神経症候群における統合的病原性メカニズムとして線維症を提案する.
心臓・腎臓の相互作用のメカニズム的な理解にフォーカスを移す
心臓神経疾患の治療対象として繊維症を特定する.

主な方法:

循環器症候群と線維症に関する最新科学文献のレビュー
心臓病と腎臓病を結びつける一般的な病理学的経路の分析
心臓神経症候群の連続体における中心的な媒介者としての線維症の概念化.

主要な成果:

繊維症は,老化,高血圧,糖尿病などの状態における炎症と酸化ストレスの一般的な結果として特定されています.
インタースティシャル線維症は心臓機能不全と慢性腎臓病の両方の一般的な特徴です.
線維症は心臓・腎臓病理学のマーカーだけでなく,潜在的な主要な要因として提案されています.

結論:

繊維症は,様々な心肺神経症候群における中心的な病原性メカニズムとして機能する.
線維症を標的とした治療は心臓・腎臓疾患の新たな治療策となるでしょう
抗線維薬の開発は心臓臓症候群の予防と治療に革命をもたらすかもしれません

キーワード:

心臓腎臓症候群繊維症心不全腎不全腎不全

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