PIEZO は血圧のニューロンの感知とバルレセプター反射を媒介する
Wei-Zheng Zeng1, Kara L Marshall1, Soohong Min2
1Howard Hughes Medical Institute, Neuroscience Department, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA.
Science (New York, N.Y.)
|October 27, 2018
まとめ
機械的に活性化されたイオンチャネルPIEZO1とPIEZO2は,体内の血圧感知メカニズムであるバロレセプションに不可欠です. マウスでは高血圧と血圧の不安定性を引き起こす.
科学分野:
- 生理学
- 分子生物学
- 神経科学
背景:
- バロレフレクスは 急性心拍数と血圧の調節に不可欠です
- バロレセプター機構感受性の基礎となる分子メカニズムは 80 年以上も謎のままである.
研究 の 目的:
- バロレセプターニューロンの機械感受性の原因となる分子成分を特定する.
- バルレセプションと血圧ホメオスタシスのPIEZOチャネルの役割を明らかにする.
主な方法:
- PIEZO1とPIEZO2の遺伝子剥離がマウスの感覚ガンジリア (ノドーゼとペトロサル) に見られる.
- 薬剤誘発反応と大動脈圧縮神経の活動を用いて,バロレフレクスの機能の評価.
- ノックアウトマウスにおける血圧の変動性と不安定性の表型分析
- PIEZO2陽性の感覚アファレントの光遺伝的活性化
主要な成果:
- PIEZO1とPIEZO2の両方の遺伝的削除は,薬剤誘発のバロレフレクスを廃止し,大動脈圧縮神経の活動を廃止しました.
- PIEZOチャネルが欠けていたマウスは,不安定な高血圧と高血圧の変動を示した.
- PIEZO2を発現するアファレントの光遺伝的刺激により,バロレフレクスの反応が成功しました.
結論:
- PIEZO1とPIEZO2は,主要なメカノセンサとして機能し,バーレセプションに不可欠です.
- これらの経路は 急性血圧の制御に不可欠です
- バロレセプターのPIEZOチャネルの機能障害は,バロレフレクスの機能不全と関連する心血管疾患に寄与する可能性があります.
さらに関連する動画
04:37Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension
Published on: June 6, 2025
745
05:57Author Spotlight: Microfluidic Channel-Based Soft Electrodes and Their Application in Capacitive Pressure Sensing
Published on: March 17, 2023
4.2K
関連する概念動画
01:24Blood Pressure
10.1K
The movement of blood in a human body, commonly referred to as blood flow, is determined by the volume of blood that traverses a certain section of the bodily system per unit time. It is the rhythmic contraction of the heart's ventricles that primarily instigates this movement. As the ventricles contract, blood is forced into the prominent arteries, which then flow from areas of greater pressure to lower pressure areas. This movement continues into smaller arteries and arterioles and...
10.1K
01:30Blood Pressure
4.5K
Blood pressure (BP) is the pressure or force of blood exerted on the artery's walls as it circulates through the body. It is essential for maintaining blood flow throughout the body.
The average BP in an adult is typically around 120/80 mmHg (millimeters of mercury). In this measurement, the numerator (120) indicates the systolic pressure, which is the pressure in the arteries during the contraction of the heart's ventricles as blood is expelled. The denominator (80) represents the...
The average BP in an adult is typically around 120/80 mmHg (millimeters of mercury). In this measurement, the numerator (120) indicates the systolic pressure, which is the pressure in the arteries during the contraction of the heart's ventricles as blood is expelled. The denominator (80) represents the...
4.5K
01:17Measurement of Blood Pressure
3.0K
Assessing blood pressure is a standard procedure executed in virtually all medical environments. The method utilized today was established over a hundred years ago by an innovative Russian doctor, Dr. Nikolai Korotkoff. The soft ticking noise, known as Korotkoff sounds, heard while taking blood pressure readings results from turbulent blood flow within the vessels. The apparatus required for this procedure includes a sphygmomanometer, a blood pressure cuff attached to a gauge, and a...
3.0K
01:28Factors affecting Blood pressure
6.8K
Several physiological and lifestyle factors influence blood pressure (BP). Understanding these factors is crucial as they are significant in patient education and blood pressure management.
Physiological Factors:
Physiological Factors:
6.8K
01:30Alterations in Blood Pressure
2.2K
Alterations in blood pressure, such as hypertension (high blood pressure) and hypotension (low blood pressure), significantly affect human health. Understanding these conditions' classifications, causes, and symptoms is essential for effective management and treatment.
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart...
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart...
2.2K
01:18Hypertension and Regulation of Blood Pressure
4.3K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
4.3K