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Updated: Feb 3, 2026

In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol
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In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol

Published on: December 30, 2016

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ヒトのT細胞におけるGARPによる潜伏TGF-β1表現と活性化の構造的基礎

Stéphanie Liénart1, Romain Merceron2,3, Christophe Vanderaa1

  • 1de Duve Institute, UCLouvain, 1200 Brussels, Belgium.

Science (New York, N.Y.)
|October 27, 2018
PubMed
まとめ

調節性T細胞はGARPを使って潜伏しているTGF-β1を活性化させる. 結晶構造は,抗体がこの相互作用を阻害し,Treg媒介の免疫抑制を抑制することを明らかにします.

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