コバルト触媒によるエポキシドのトリフルオロメトキシル化
Jie Liu1, Yongliang Wei1, Pingping Tang1,2
1State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry , Nankai University , Tianjin 300071 , China.
Journal of the American Chemical Society
|October 30, 2018
まとめ
新しいコバルト触媒反応により,エポキシドから近隣のトリフローロメトキシヒドリンの直接合成が可能である. この効率的な方法は,温和な条件下で貴重なトリフローロメトキシル化化合物への簡単な経路を提供します.
科学分野:
- 有機化学
- カタリシス
- フッ素化学
背景:
- エポキシドは多用途の合成中間物質です
- トリフルオロメトキシル化は,医薬品化学における重要な変換である.
- トリフローロメトキシル化化合物を合成するための直接的な方法は,非常に求められています.
研究 の 目的:
- エポキシドのリング開き反応のための新しい触媒方法の開発.
- トリフローロメチル硫酸塩を用いてエポキシドの核性トリフローロメトキシル化を実現する.
- 近隣のトリフローロメトキシヒドリンを効率的かつ選択的に合成する.
主な方法:
- エポキシドのコバルト触媒リング開封
- トリフローロメチル硫酸塩を用いた核性トリフローロメチル酸化.
- 軽度の反応条件が採用された.
主要な成果:
- 近隣のトリフローロメトキシヒドリンを合成するための直接的かつ効率的な経路が確立されました.
- この反応は,特に末端のエポキシドで,良好な化学的および地域選択性を示した.
- 幅広いエポキシドがターゲット製品に成功しました.
結論:
- 開発されたコバルト触媒反応は,トリフローロメトキシヒドリンを製造するための簡単な方法を提供します.
- このアプローチは,trifluoromethoxy群を有機分子に導入するための貴重なツールを提供します.
- このメソッドの効率性と選択性により,合成用途には魅力的です.
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