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Updated: Feb 3, 2026

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生体細胞におけるEGFRコンフォーマーションダイナミクスの単分子回転

Youngchan Park1, Sangwon Shin2, Hyeonggyu Jin2

  • 1Department of Chemistry , KAIST , Daejeon 34141 , Republic of Korea.

Journal of the American Chemical Society
|November 2, 2018
PubMed
まとめ

研究者らは単一分子イメージングのための新型のジャイロスコピックプラズモニックナノ粒子を開発した. この画期的な発見により タンパク質の構成の変化と 細胞の相互作用が視覚化され 細胞メカニズムへの新たな洞察が提供されます

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Equation of Rotational Dynamics01:08

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Angular variables are introduced in rotational dynamics. Comparing the definitions of angular variables with the definitions of linear kinematic variables, it is seen that there is a mapping of the linear variables to the rotational ones. Linear displacement, velocity, and acceleration have their equivalents in rotational motion, which are angular displacement, angular velocity, and angular acceleration. Similar to the rotational variables, a mapping exists from Newton's second law of motion...
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Conformity

Conformity is the change in a person’s behavior to go along with the group, even if that person does not agree with the group.
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At room temperature, the chair conformer of cyclohexane undergoes rapid ring flipping between two equivalent chair conformers at a rate of approximately 105 times per second. These two chair conformers are in equilibrium. The rapid ring flipping results in the interconversion of the axial proton to an equatorial proton and an equatorial to the axial proton. Such interconversions are too rapid and cannot be detected on the NMR timescale. Hence, the NMR spectrometer cannot distinguish between the...
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The axial and equatorial protons in cyclohexane can be distinguished by performing a variable-temperature NMR experiment. In this process, except for one proton, the remaining eleven protons are replaced by deuterium. The deuterium substitution avoids the possible peak splitting caused by the spin-spin coupling between the adjacent protons. The remaining proton flips between the axial and equatorial positions.
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Unlike ethane and propane that have only two major conformations, butane has more than two conformers. The staggered form of butane in which the bulky methyl groups on the two carbons are placed on opposite sides, that is, at a dihedral angle of 180°, is the lowest energy, most stable form — called the anti conformer. This conformation is stabilized due to the absence of steric repulsion between the largely spaced out methyl groups. The other two staggered conformations are...
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