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Zinc-finger Nuclease Enhanced Gene Targeting in Human Embryonic Stem Cells
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CRBNによるタリドミド類の標的となるヒトC2H2亜鉛指の分解を定義する

Quinlan L Sievers1,2, Georg Petzold3, Richard D Bunker3

  • 1Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.

Science (New York, N.Y.)
|November 3, 2018
PubMed
まとめ

タリドミド類はCys2- His2亜鉛指タンパク質を標的とし,CRL4CRBN E3ユビキチンリガゼによって分解される. この研究は新しい亜鉛指デグロンを特定し,以前は薬効性がないと考えられていた治療標的を拡大しました.

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