アメリカ移民がヒトの腸内微生物を西洋化
Pajau Vangay1, Abigail J Johnson2, Tonya L Ward2
1Bioinformatics and Computational Biology Program, University of Minnesota, Minneapolis, MN 55455, USA.
Cell
|November 3, 2018
まとめ
アメリカへの移民は腸内微生物の多様性と機能を急速に低下させ,アメリカに関連した菌株によってネイティブの微生物が置き換えられる. 代々 代々 肥満によって これらの変化は悪化します
科学分野:
- 人間 の 健康
- 微生物群の研究
- 移民に関する研究
背景:
- メタボリック疾患は 原因が不明で アメリカ移民の集団で 流行しています
- 代謝疾患における腸内微生物の役割は確立されていますが,移民の影響は研究されていません.
研究 の 目的:
- 腸内微生物の組成と機能に及ぼす影響を調査する.
- 移住が微生物の多様性や 代謝の健康にどのように影響するかを理解する
主な方法:
- タイとアメリカのハムン族とカレン族の糞便,食事,人体測定データを収集した.
- 微生物群の分析のために 16Sと深層ショットガンメタゲノム配列を解析した.
- 第1世代と第2世代の移民,移民前と移民後の個人,米国生まれの対照群を含む.
主要な成果:
- アメリカへの移住は 直ちに腸内微生物の多様性と機能の喪失を引き起こしました
- 移民後,アメリカに関連した微生物の株と機能が 移動した.
- これらの変化は,米国での居住期間,肥満,そして世代を超えて強まりました.
結論:
- アメリカへの移民は 腸内微生物を大きく破壊します
- 微生物群の変化は 居住期間,肥満,世代間の影響と関連しています
- 移民の代謝疾患の要因として 腸内微生物群を強調しています
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