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Updated: Feb 3, 2026

Peptide-based Identification of Functional Motifs and their Binding Partners
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免疫融合結合モチーフに基づく改良されたアンチフォスフォチロシン抗体

Yun Mou1,2, Xin X Zhou1, Kevin Leung1

  • 1Department of Pharmaceutical Chemistry , University of California, San Francisco , San Francisco , California 94143 , United States.

Journal of the American Chemical Society
|November 7, 2018
PubMed
まとめ

研究者は,保存された結合モードを明らかにし,汎特異性フォスフォチロジン (pY) 抗体の最初の結晶構造を決定した. この洞察は,信号伝達経路の研究のための強化された結合親和性を持つ改善されたpY抗体変異体の設計を可能にしました.

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