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Updated: Feb 3, 2026

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ディヒドロフォラート還元酵素における結合基質pKaに対する進化的影響

Anil R Mhashal1, Yaron Pshetitsky1, Christopher M Cheatum2

  • 1Department of Chemistry , Bar-Ilan University , Ramat-Gan 5290002 , Israel.

Journal of the American Chemical Society
|November 7, 2018
PubMed
まとめ

ディヒドロフォラート還元酶 (DHFR) という酵素は 基板により効果的に結合するよう進化した. この研究では 酵素塩基度の増加と活性部位の水分減少が相関しており 進化的適応を示唆しています

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