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Updated: Feb 3, 2026

Differentiation of Human Pluripotent Stem Cells into Insulin-Producing Islet Clusters
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微生物で生成されたイミダゾールプロピオネートはmTORC1を通じてインスリンシグナルを損なう

Ara Koh1, Antonio Molinaro1, Marcus Ståhlman1

  • 1Department of Molecular and Clinical Medicine/Wallenberg Laboratory, Institute of Medicine, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden.

Cell
|November 8, 2018
PubMed
まとめ

2型糖尿病では腸内微生物の代謝物であるイミダゾールプロピオネートが増加し,インスリン信号伝達経路を阻害することで,グルコース耐性を低下させる. この発見は,代謝疾患の発症におけるイミダゾールプロピオネットの潜在的な役割を示唆する.

キーワード:
国税局ヒスティジンイミダゾールプロピオネートmTORC1について微生物群p38γp62 について

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