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Cryo-EMは,完全な長さの5-HT3A受容体の2つの異なるセロトニン結合構造を明らかにする

Sandip Basak1, Yvonne Gicheru1, Shanlin Rao2

  • 1Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, USA.

Nature
|November 8, 2018
PubMed
まとめ

5HT3Aセロトニン受容体は,吐き気抑制薬の標的であり,セロトニン結合時に形状の変化を経験する. これらの構造的変化がチャンネルを活性化し イオン浸透の新たな経路を明らかにします

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