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SWI/SNF複合体は,YAPとTAZの機械的に調節された阻害剤である

Lei Chang1, Luca Azzolin1, Daniele Di Biagio1

  • 1Department of Molecular Medicine, University of Padua, Padua, Italy.

Nature
|November 8, 2018
PubMed
まとめ

SWI/SNF複合体は,ARID1Aを介して,YAP/TAZの活動を抑制する. ARID1Aの喪失または細胞メカニズムの増加は,YAP/TAZ主導の癌を促進し,新しい腫瘍抑制メカニズムを明らかにします.

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