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Visualizing the Conformational Dynamics of Membrane Receptors Using Single-Molecule FRET
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セロトニン5-HT3受容体のコンフォーマショナルトランジション

Lucie Polovinkin1, Ghérici Hassaine2, Jonathan Perot1

  • 1CNRS, Université Grenoble Alpes, CEA, IBS, Grenoble, France.

Nature
|November 8, 2018
PubMed
まとめ

研究者たちは 吐き気やIBSの 重要な標的であるセロトニン5HT3受容体を 視覚化して ゲートメカニズムを明らかにしました これらの構造は,前例のない詳細でリガンド結合と形状の変化を捕捉します.

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