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Updated: Feb 2, 2026

Purification of the Membrane Compartment for Endoplasmic Reticulum-associated Degradation of Exogenous Antigens in Cross-presentation
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Purification of the Membrane Compartment for Endoplasmic Reticulum-associated Degradation of Exogenous Antigens in Cross-presentation

Published on: August 21, 2017

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WDFY4は,ウイルスと腫瘍の抗原への反応としてクロスプレゼンテーションが必要である

Derek J Theisen1, Jesse T Davidson1,2, Carlos G Briseño1

  • 1Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Science (New York, N.Y.)
|November 10, 2018
PubMed
まとめ

BEACHドメインタンパク質WDFY4は,マウスにおける樹状細胞 (cDC1) によるクロスプレゼンテーションに不可欠である. このプロセスは CD8+ T細胞の活性化に不可欠であり,効果的な抗ウイルスおよび抗腫瘍免疫を可能にします.

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