位置の安定性と膜の占有性は,皮膚線維細胞のホメオスタシスを定義する

Edward Marsh¹, David G Gonzalez¹, Elizabeth A Lathrop¹

¹Department of Genetics, Yale School of Medicine, New Haven, CT 06510, USA.

Cell

|November 13, 2018

まとめ

ネズミの皮膚線維細胞の位置は,隣人が失われても安定しています. 細胞膜はダイナミックに広がり隙間を埋めて組織構造を老化中に維持します

科学分野:

細胞生物学
皮膚科
組織ホメオスタシス

背景:

繊維芽細胞は臓器の構造と機能に不可欠です
フィブロブラストのホメオスタシスを in vivoで維持するメカニズムは完全に理解されていません.

研究の目的:

生きたマウスのホメオスタシスの維持に不可欠なフィブロブラストの行動を調査する.
皮膚の繊維細胞の安定性の鍵となる原理と細胞機構を定義する.

主な方法:

生きたマウスの個々の皮膚線維芽細胞の縦断追跡
線維細胞の位置的安定性と膜動態の分析
Rac1に依存するメカニズムと老化効果の調査

主要な成果:

フィブロブラストの位置は時間とともに安定し,隣接する細胞の喪失にもかかわらず持続します.
繊維細胞膜はダイナミックで,Rac1に依存するプロセスを通じて,失われた隣人によって残された空間を占有するために拡張します.
ポジションの安定性と細胞の占有量は,核組織のギャップであっても,老化中に維持されます.

結論:

位置の安定性と細胞占有量は,皮膚線維細胞のホメオスタシスの基本原理である.
移動なしの膜拡張は,生涯にわたってフィブロブラストのホメオスタシスと組織の整合性を維持する主要な細胞メカニズムです.

キーワード:

年老化細胞の行動フィブロブラストイントラバイタル画像メゼンキム皮膚のホメオスタシス

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