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Updated: Feb 2, 2026

Optical Control of a Neuronal Protein Using a Genetically Encoded Unnatural Amino Acid in Neurons
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Optical Control of a Neuronal Protein Using a Genetically Encoded Unnatural Amino Acid in Neurons

Published on: March 28, 2016

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遺伝子でコードされた非正規のアミノ酸でタンパク質の安定性を高める

Jack C Li1, Tao Liu1, Yan Wang1

  • 1Department of Chemistry and Skaggs Institute for Chemical Biology , The Scripps Research Institute , La Jolla , California 92037 , United States.

Journal of the American Chemical Society
|November 16, 2018
PubMed
まとめ

研究者は非正規のアミノ酸を組み込むことで 熱的安定性を高めるタンパク質を設計しました E. coli ホモセリンO-スッキニルトランスフェラーゼ (metA) の (p-ベンゾイルフェニル) アラニンを用いた単一の変異により,溶解温度が21°C上昇した.

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