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酵母生物ハイブリッドの光駆動微細化学生産

Junling Guo¹, Miguel Suástegui¹, Kelsey K Sakimoto^2,3

¹Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA. junling.guo@wyss.harvard.edu neel.joshi@wyss.harvard.edu.

Science (New York, N.Y.)

|November 17, 2018

まとめ

この研究は,インジウム・フォスフィードナノ粒子と持続可能な化学合成のための工学酵母を用いた新しいバイオ無機ハイブリッドプラットフォームを導入します. このシステムは,光によるコファクター再生により,価値ある医薬品前駆体であるシキミ酸を効率的に生成します.

科学分野:

バイオテクノロジー
材料科学
合成生物学

背景:

半導体光採集と細胞の代謝能力を組み合わせることで持続可能で効率的な化学合成を可能にします
このようなハイブリッドシステムの開発は,バイオマニュファクチャリングの進歩と新しい生産プラットフォームの創造に不可欠です.

研究の目的:

インジウム・フォスフィードナノ粒子と設計されたサカロマイセス・セレヴィシアを統合した模組型のバイオ無機ハイブリッドプラットフォームを作成する.
光駆動コファクター再生と効率的な代謝産生のためのプラットフォームの能力を実証する.

主な方法:

光を集める高効率のインジウム・フォスフィードナノ粒子を利用した.
バイオカタリシス用遺伝子組み換えサッカロミセア (酵母菌) が使用されている.
イーストの細胞系コファクターの再生経路によるナノ粒子集光

主要な成果:

バイオ無機ハイブリッドシステムはナノ粒子から光生成された電子を収穫することに成功しました
エンジニアリングされた酵母はこれらの電子を細胞酸化再酸化因子再生に利用した.
薬剤と精細化学品の重要な前駆体であるシキミ酸の炭素とエネルギー効率の良い生産を達成しました.

結論:

開発されたプラットフォームは,生物合成とコファクター再生の分離を可能にし,プロセスの効率を高めます.
このバイオハイブリッドアプローチは,複雑で機能的なバイオ製造プロセスを設計するための汎用的なプラットフォームを提供します.
非有機ナノマテリアルを微生物工学と統合することで,持続可能な化学生産の可能性を強調する.

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