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Updated: Feb 2, 2026

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Published on: May 15, 2019

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PROTAC媒介による劣化によるFakのキナーゼ独立機能への対処

Philipp M Cromm1, Kusal T G Samarasinghe1, John Hines1

  • 1Department of Molecular, Cellular & Developmental Biology , Yale University , New Haven , Connecticut 06511 , United States.

Journal of the American Chemical Society
|November 17, 2018
PubMed
まとめ

小分子によるタンパク質分解は 新しい治療戦略を提示します 新しい焦点粘着キナーゼ (FAK) 降解剤であるPROTAC-3は,腫瘍細胞の移動と侵入を効果的に抑制し,既存の阻害剤を上回ります.

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