ディエンとフォスフィン酸化物のエナンチオセレクティブカップリング
Shao-Zhen Nie1,2, Ryan T Davison1, Vy M Dong1
1Department of Chemistry , University of California , Irvine , California 92697 , United States.
Journal of the American Chemical Society
|November 20, 2018
まとめ
この研究は,単純なダイエンとフォスフィン酸化物からキラルアリルフォスフィン酸化物を生成するための新しいパラジウム触媒反応を導入する. この突破は 優れた制御を伴う 有価な有機リン化合物への 新たな経路を提供します
科学分野:
- 有機化学
- カタリシス
- オルガノフォスファース化学
背景:
- アリル酸ホスフィンは重要な合成中間物質である.
- キラルアリルフォスフィン酸化物を合成するための既存の方法は限られている.
- 非対称な触媒は,エナチオメリックに濃縮された化合物を生成するための強力なアプローチを提供します.
研究 の 目的:
- 1,3-ダイエンの新しいパラジウム触媒型分子間ヒドロフォスフィニレーションを開発する.
- キラルアリルフォスフィン酸化物の形成において高いエナンチオセレクティブ性と地域選択性を達成する.
- 有価な有機リン基を生産する新しい方法を確立する
主な方法:
- パラジウム触媒による結合反応
- 基質として商品の1,3-ダイエンを利用する.
- 空気に安定したフォスフィン酸化物を結合パートナーとして使用する.
主要な成果:
- キラル・アリル・フォスフィン・オキシドの合成に成功
- 反応において高いエナチオとレギオコントロールを示した.
- ダイエンの第1次非対称的水リン酸化を確立した.
結論:
- 開発されたPd触媒方式は,キラルアリルフォスフィン酸化物への効率的な経路を提供します.
- この方法論は,複雑な有機リン化合物を合成するためのツールキットを拡張します.
- 反応の高い選択性により,キラル構造ブロックの構築に価値があります.
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