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Updated: Feb 2, 2026

Functional Assessment of BRCA1 variants using CRISPR-Mediated Base Editors
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DYNLL1は,BRCA1欠乏細胞におけるDNA末端切除を制限するためにMRE11に結合する

Yizhou Joseph He1, Khyati Meghani1, Marie-Christine Caron2,3

  • 1Division of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

Nature
|November 23, 2018
PubMed
まとめ

科学者はDYNLL1が DNAの修復に不可欠な DNA末端切除を制限することを発見しました DYNLL1を阻害すると,BRCA1変異がんのDNA修復が回復し,化学療法に対する反応が改善される可能性があります.

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