プロトカデリン-1は,新世界ハンタウイルスによる細胞侵入に不可欠である
Rohit K Jangra1, Andrew S Herbert2, Rong Li3
1Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.
Nature
|November 23, 2018
まとめ
プロトカデリン-1 (PCDH1) はハンタウイルスのヒト細胞への侵入に不可欠です. PCDH1を阻害することで,ハンタウイルス肺症候群 (HPS) と関連する感染症を予防できます.
科学分野:
- ウイルス学
- 分子生物学
- 免疫学
背景:
- ハンタウイルス肺症候群 (HPS) は,動物性ハンタウイルスによって引き起こされる重症でしばしば致命的な呼吸器疾患である.
- 特定の抗ウイルス治療法やハンタウイルス感染に対する感受性の分子決定因子は存在しません.
研究 の 目的:
- 肺内皮細胞へのハンタウイルスの侵入と感染の分子決定因子を特定する.
- HPSの潜在的治療目標を探求する.
主な方法:
- ハンタウイルスの侵入を研究する細胞ベースのインビトロ測定法
- アンデスウイルス (ANDV) 感染のシリアの黄金ハムスターモデルを用いた体内研究.
- 遺伝子操作で PCDH1の発現を抑制する
主要な成果:
- プロトカデリン-1 (PCDH1) は,アンデスウイルス (ANDV) とシンノブレウイルス (SNV) の侵入に不可欠な宿主因子として特定されました.
- ハンタウイルスの表面グリコタンパク質は,細胞への侵入のためにPCDH1に直接結合する.
- PCDH1の遺伝的消去は,致命的なANDV感染に対する有意な耐性をハムスターに与えました.
結論:
- PCDH1は新世界ハンタウイルス感染の重要な決定因子です.
- PCDH1を標的にすることは,ハンタウイルス感染症とHPSと戦うための潜在的な治療戦略です.
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