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マノースは腫瘍の成長を阻害し,化学療法効果を高める
Pablo Sierra Gonzalez1, James O'Prey1, Simone Cardaci1,2
1Cancer Research UK Beatson Institute, Glasgow, UK.
Nature
|November 23, 2018
まとめ
マノース糖は腫瘍の成長を遅らせ,特に化学療法と併用すると,癌細胞の死滅を増加させます. この単純な砂糖治療は様々な癌の治療に有望であり,フォスフォマノースイソメラーゼ (PMI) レベルに関連しています.
科学分野:
- 癌における代謝経路
- 糖の代謝と癌
- がん治療と薬剤耐性
背景:
- 腫瘍は細胞の代謝が変化し 潜在的脆弱性を示します
- 多くの腫瘍の特徴です.
- 異なる糖質に対する 細胞の反応を調査することで 治療目標が明らかになります
研究 の 目的:
- モノサッカライドマノースが腫瘍細胞の成長と化学療法への反応に及ぼす影響を調査する.
- マノースの抗腫瘍作用の仕組みを解明する
- マノースががん治療の有効な治療策であるかどうかを判断する.
主な方法:
- マウスにおける様々な腫瘍のインビトロおよびインビボ研究.
- マノースの経口投与と化学療法との併用
- 糖分解,TCAサイクル,ペントースリン酸経路,およびグリカン合成の代謝分析.
- 抗アポプトシスタンパク質レベルとフォスフォマノースイソメラーゼ (PMI) の活性に関する評価
- 患者の腫瘍サンプルにおけるPMI値の組織マイクロアレイ分析
主要な成果:
- マノースは成長を阻害し,化学療法による細胞死をインビトロおよびインビボで増強する.
- マノースはマノース6酸化物として蓄積され,グルコース代謝とグリカン合成を阻害する.
- マノースと化学療法の組み合わせは,Bcl-2ファミリーのタンパク質に影響を与え,細胞を死滅させる.
- マノースに対する腫瘍の感受性は,フォスフォマノースイソメラーゼ (PMI) レベルと逆相関する.
- 患者と腫瘍の種類によってPMIレベルは著しく変化し,バイオマーカーの可能性を示唆しています.
結論:
- マノースは細胞の代謝を妨害し,がん細胞を化学療法に敏感にすることで,抗腫瘍作用を示す.
- マノース療法の有効性は,予測バイオマーカーとして機能するフォスフォマノースイソメラーゼ (PMI) レベルに関連しています.
- マノースは様々な種類の癌に対する 単純で安全で選択的な治療法です
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