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人間のTRPM2の構造とゲートメカニズム

Longfei Wang1,2, Tian-Min Fu3,2, Yiming Zhou4,5

  • 1Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

Science (New York, N.Y.)
|November 24, 2018
PubMed
まとめ

この研究では,カルシウム (Ca2+) とアデノシン・ディフォスファート (ADP) - リボース (ADPR) がTRPM2チャネルを活性化する方法が明らかになりました. 構造的な洞察は,Ca2+とADPRの結合が構造変化を引き起こし,チャネル孔を開くことを示しています.

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