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関連する概念動画

Metallic Solids02:37

Metallic Solids

20.6K
Metallic solids such as crystals of copper, aluminum, and iron are formed by metal atoms. The structure of metallic crystals is often described as a uniform distribution of atomic nuclei within a “sea” of delocalized electrons. The atoms within such a metallic solid are held together by a unique force known as metallic bonding that gives rise to many useful and varied bulk properties.
All metallic solids exhibit high thermal and electrical conductivity, metallic luster, and malleability....
20.6K
Structures of Solids02:22

Structures of Solids

17.7K
Solids in which the atoms, ions, or molecules are arranged in a definite repeating pattern are known as crystalline solids. Metals and ionic compounds typically form ordered, crystalline solids. A crystalline solid has a precise melting temperature because each atom or molecule of the same type is held in place with the same forces or energy. Amorphous solids or non-crystalline solids (or, sometimes, glasses) which lack an ordered internal structure and are randomly arranged. Substances that...
17.7K
Network Covalent Solids02:18

Network Covalent Solids

16.2K
Network covalent solids contain a three-dimensional network of covalently bonded atoms as found in the crystal structures of nonmetals like diamond, graphite, silicon, and some covalent compounds, such as silicon dioxide (sand) and silicon carbide (carborundum, the abrasive on sandpaper). Many minerals have networks of covalent bonds.
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...
16.2K
What are Viruses?00:50

What are Viruses?

128.1K
Overview
128.1K
Molecular and Ionic Solids02:54

Molecular and Ionic Solids

20.1K
Crystalline solids are divided into four types: molecular, ionic, metallic, and covalent network based on the type of constituent units and their interparticle interactions.
Molecular Solids
Molecular crystalline solids, such as ice, sucrose (table sugar), and iodine, are solids that are composed of neutral molecules as their constituent units. These molecules are held together by weak intermolecular forces such as London dispersion forces, dipole-dipole interactions, or hydrogen bonds, which...
20.1K
Molecular Comparison of Gases, Liquids, and Solids02:26

Molecular Comparison of Gases, Liquids, and Solids

55.1K
Particles in a solid are tightly packed together (fixed shape) and often arranged in a regular pattern; in a liquid, they are close together with no regular arrangement (no fixed shape); in a gas, they are far apart with no regular arrangement (no fixed shape). Particles in a solid vibrate about fixed positions (cannot flow) and do not generally move in relation to one another; in a liquid, they move past each other (can flow) but remain in essentially constant contact; in a gas, they move...
55.1K

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Monitoring Protein Adsorption with Solid-state Nanopores
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Monitoring Protein Adsorption with Solid-state Nanopores

Published on: December 2, 2011

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バイオ認識の固体ナノポールを用いて単一のウイルスを識別する

Akihide Arima1, Ilva Hanun Harlisa2, Takeshi Yoshida1

  • 1The Institute of Scientific and Industrial Research , Osaka University , 8-1 Mihogaoka , Ibaraki, Osaka 567-0047 , Japan.

Journal of the American Chemical Society
|November 27, 2018
PubMed
まとめ

研究者は単一のウイルスを正確に検出するための新しいペプチドナノポア免疫センサーを開発しました. このテクニックは,デジタルタイピングを可能にするトランスロケーションダイナミクスを変更することによって,合成ペプチドを使用してインフルエンザAウイルスを識別します.

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Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores
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Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

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Validating Whole Genome Nanopore Sequencing, using Usutu Virus as an Example
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Validating Whole Genome Nanopore Sequencing, using Usutu Virus as an Example

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関連する実験動画

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Monitoring Protein Adsorption with Solid-state Nanopores

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Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores
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科学分野:

  • バイオテクノロジーとナノテクノロジー
  • 分析化学
  • 感染症 診断

背景:

  • 免疫センシングは,病原体検出のための特定の分子相互作用に依存しています.
  • 人工ナノ孔は単粒子の分析のためのプラットフォームを提供します.
  • 選択的で敏感なバイオセンサの開発は 病気の診断に不可欠です

研究 の 目的:

  • 単一のウイルスを選択的に識別するためのペプチドベースのナノポアシステムを設計する.
  • 合成ペプチドを インフルエンザAウイルスの 検知装置として利用する.
  • 変異した転移ダイナミクスに基づく ウイルスのデジタルタイプ化を実証する.

主な方法:

  • ヘマグルチニン抗体を模倣するオリゴペプチドで 人工ナノ孔壁の機能化
  • ナノチャネルにおけるウイルス転移ダイナミクスに対するペプチド-ウイルス相互作用の影響を調査する.
  • 抵抗性パルス信号を分析して 特定のウイルスを区別する

主要な成果:

  • 合成ペプチドは,バイリオン-ナノポールの相互作用に特異性を与えた.
  • リンガンド結合は,インフルエンザAウイルスの転位動態を混乱させた.
  • インフルエンザウイルスのデジタルタイプ化は,抵抗性脈拍の鈍度分析によって達成された.

結論:

  • ペプチドナノポールのアプローチは,多用途の免疫感知のための単粒子の感受性を可能にします.
  • この方法は,ウイルスおよび細菌のスクリーニングで広範な応用の可能性を示しています.
  • この技術は感染症の診断の進歩を 約束しています