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ニトリルとシアノヒドリン水分化のための高活性プラチナ触媒:高通量技術による触媒設計とリガンドスクリーニング
Xiangyou Xing1,2, Chen Xu1,2, Bo Chen1
1Shenzhen Grubbs Institute , Southern University of Science and Technology (SUSTech) , Shenzhen , 518055 , China.
Journal of the American Chemical Society
|November 29, 2018
まとめ
新しいプラチナ触媒は,穏やかな温度でナトリルとシアノヒドリンを効率的に水分化します. これらの"ドナー-受容体"触媒,特にDPPFリガンドを持つものは,化学および医薬品の研究のためのアミド合成を進める高いターンオーバー数を提供します.
科学分野:
- カタリシス
- 有機金属化学
- 合成化学
背景:
- 化学および製薬業界で不可欠なアミドを合成するには,ニトリル水分化が不可欠です.
- 既存の方法は,環境温度反応のための効率的な二相触媒の欠如やシアノヒドリンの水分化における課題を含む制限に直面しています.
研究 の 目的:
- 強化されたニトリルとシアノヒドリンの水分化のための新しい"ドナー-受容体"プラチナ触媒を設計する.
- 環境または穏やかな温度で高回転数と活性を持つ触媒を特定する.
主な方法:
- 電子が豊富で,電子が欠けているリガンドを配列することによって"ドナー-受容体"プラチナ触媒の開発.
- バイデントリガンドのライブラリをスクリーニングするために高通量で自動化されたワークフローを使用します.
- DPPFと改変されたフェロセンのリガンドから派生した触媒の合成と評価.
主要な成果:
- 2a (DPPFを使用) などの優れた反応性を示す"ドナー-受容体"プラチナ触媒の発見.
- 40 °Cで幅広いニトリルとシアノヒドリンの水分化に成功し,優れた周回率を保持しています.
- 室温で最も高い活性を示す改変された電子に富んだリガンドを持つ触媒2cの識別.
結論:
- "ドナー-受容体"触媒設計戦略は,ナトリルとシアノヒドリンの水分化を効果的に強化します.
- DPPFベースのプラチナ触媒は,アミド合成における重要な進歩を表しています.
- フォスフィンリガンドの電子提供能力は,触媒効率と相関し",ドナー-受容体"仮説を支持する.
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