ナノスケール金属有機層 放射線療法-放射力学療法
Journal of the American Chemical Society
|November 29, 2018
まとめ
2つの新しいナノスケール金属有機層 (nMOLs),Hf12-IrとHf6-Irは強力な抗がん効果を示しています. これらの材料は放射線治療と放射線動力療法を強化し 低用量のX線で99%以上の腫瘍の収縮につながります
科学分野:
- 材料科学
- ナノテクノロジー
- 生物医学工学
背景:
- ナノスケール金属有機層 (nMOL) は,ナノスケール金属有機フレームワーク (nMOF) から派生した新興2D結晶材料である.
- nMOLは,2Dナノマテリアルのアニソトロピク特性と組み合わせた調節可能な構造と組成を提供しており,生物医学的な用途に有望です.
- 放射線治療 (RT) と放射線動力療法 (RDT) は癌治療の重要な方法である.
研究 の 目的:
- RTとRDTを組み合わせた新しいnMOLを開発する.
- Hf12- IrとHf6- Ir nMOLの抗癌効果を調査する.
- これらのnMOLによってRTとRDTの強化のための行動メカニズムを探求する.
主な方法:
- 2つの新しいnMOL,Hf12-IrとHf6-Irの合成,Hf12とHf6の二次構造単位 (SBU) と光敏感化イリジウムベースのリガンドを使用する.
- Hf12-IrとHf6-Irで治療された癌細胞のX線照射
- 放射性酸素種 (ROS) 生成 (ヒドロキシルラジカル,シングレット酸素,超酸化アニオン) の分析
- 癌細胞死 (RDTによる即死,RTによる生殖性死) と腫瘍逆行の評価 in vivo.
主要な成果:
- Hf12-IrとHf6-Irは効率的にX線を吸収し,RTとRDTの両方を強化しました.
- nMOLのX線照射により,ヒドロキシルラジカル (RT強化) と刺激されたイリジウムリガンドが生成され,シングレット酸素と超酸化アニオンが生成される (RDT活性化).
- nMOLは,RDTとRTの両方で,著しい癌細胞死亡を誘導し,低X線量 (0. 5 × 5 Gy) で> 99%の腫瘍回帰を達成しました.
結論:
- Hf12-IrとHf6-Irは2Dナノマテリアルの新しいクラスで,がん治療のシナージーを生み出します.
- これらのnMOLはRTとRDTを効果的に結合し,抗がん効果を高める有望な戦略を提供します.
- 開発されたnMOLは,副作用を最小限に抑え,低用量で高効率のがん治療の可能性を示しています.
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