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NP220は,統合されていないレトロウイルスDNAの静止を媒介する

Yiping Zhu1,2,3, Gary Z Wang2,3, Oya Cingöz2,3

  • 1Howard Hughes Medical Institute, Columbia University, New York, NY, USA.

Nature
|November 30, 2018
PubMed
まとめ

外来DNAは先天的な免疫を誘発し,未統合のレトロウイルスDNAの表遺伝的沈黙につながります. 研究者らは,NP220とHUSH複合体を,この静止メカニズムにおける重要な要因として特定し,ウイルスの複製を制御する上で決定的な役割を果たした.

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