セクレチン: 燃える 秘密 を 秘めた 古い ホルモン
Randall L Mynatt1, Eric Ravussin1
1Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA.
Cell
|December 1, 2018
まとめ
腸内ホルモンのセクレチンは 食事後の茶色の脂肪組織で 熱生成を刺激します この発見は,飽和感とエネルギー消費を調節するセレクチンの新しいメカニズムを明らかにしています.
科学分野:
- 内分泌学
- メタボリズム
- 神経科学
背景:
- 食事誘発発熱生成は通常,腸-脳-茶色脂肪組織 (BAT) 軸によって説明される.
- この軸は交感神経系を通して 発熱を媒介する.
研究 の 目的:
- 食事誘発熱生成におけるセクレチンの役割を調査する.
- 飽和感とエネルギー消費を制御する新しいメカニズムを特定する.
主な方法:
- ブラウン脂肪組織におけるセクレチンの受容体への結合を研究した.
- サーモゲネシスと食物の摂取に対するセクレチンの影響を評価した.
主要な成果:
- 食後に腸から放出されるセクレチンは,BATの受容体と結合する.
- セクレチンはBATにおける熱生成を直接刺激する.
- セクレチン投与は食物摂取を抑制した.
結論:
- セクレチンは,茶色の脂肪組織を通して熱生成を刺激する直接的な役割を果たします.
- セクレチンは飽和感の新たな調節剤として働き,食物の摂取に影響を与えます.
- この発見は 代謝調節における腸-脳-BAT軸に 新たな視点を 提供しています
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