トレーニングされた免疫と肺における局所的な先天的な免疫記憶
Mihai G Netea1, Leo A B Joosten2
1Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands; Department for Immunology & Metabolism, Life and Medical Sciences Institute (LIMES), University of Bonn, 53115 Bonn, Germany.
Cell
|December 1, 2018
まとめ
訓練された免疫は エピジェネティック再プログラムによって 感染症から守ります 新しい研究では ウイルスの感染が 肺のマクロファージで局所的に引き起こされ CD8+ T細胞のシグナル伝達によって引き起こされると示しています
科学分野:
- 免疫学
- 感染症
- エピジェネティクス
背景:
- トレーニングされた先天的な免疫は,エピジェネティックな改変によって様々な病原体に対して広範な保護を提供します.
- この現象は 骨髄細胞とその前体細胞の 機能的な再プログラムを含みます
研究 の 目的:
- 肺の微小環境内での訓練された免疫の誘導を調査する.
- ウイルスの感染後に局所的に訓練された免疫を駆動する細胞および分子メカニズムを特定する.
主な方法:
- マウスのウイルス感染モデル
- アルベオラマクロファージの再プログラム分析
- CD8+ T細胞の関与とサイトカインの放出 (IFNγ) の評価
主要な成果:
- ウイルスの感染は 培養された免疫を誘発し アルベオラマクロファージに局所する.
- エフェクタ CD8+ Tリンパ球によって放出されたインターフェロン- ガンマ (IFNγ) が主要なイニシアターとして特定されました.
- 肺の骨髄細胞の 機能的再プログラムが示されています
結論:
- ウイルスの感染は肺に局所的な免疫を誘発する.
- エフェクタ CD8+ T細胞とIFNγは,この局所的な訓練された免疫反応の開始において重要な役割を果たします.
- 肺系内の免疫記憶の 新しいメカニズムを強調しています
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