海馬CA2から横隔膜への回路は 社会的攻撃性を抑制する
Felix Leroy1, Jung Park2, Arun Asok2
1Department of Neuroscience, The Kavli Institute for Brain Science, Mortimer B. Zuckerman Mind Brain Behavior Institute, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA. felxfel@aol.com.
Nature
|December 7, 2018
まとめ
ヒポカンプスのCA2領域のピラミッド神経は 社会的攻撃性を促進します この経路は lateral septumと arginine vasopressinを巻き込み 動機づけられた行動に影響を与えます
科学分野:
- 神経科学
- 行動神経科学
- 神経生物学
背景:
- ヒッポカンプスは 宣言的な記憶に不可欠です
- 社会的攻撃性などの 動機づけられた行動を 制御する役割は 十分に理解されていません
研究 の 目的:
- 社会的攻撃性を促進するヒポカンパのCA2領域の出力の役割を調査する.
- 神経回路と 分子メカニズムを解明する
主な方法:
- マウスの電気生理学的記録
- オプトジェネティックとケモジェネティックによる 神経回路の操作
- 社会的攻撃性に対する行動分析
- アルギニンバソプレシン受容体を標的とした薬理学的介入
主要な成果:
- ヒポキャンパスのCA2ピラミッドニューロンは マウスの社会的攻撃性を促進します
- 横隔膜へのCA2出力は 攻撃の前に増幅されます
- この経路は 腹中下垂体を消毒して 攻撃を誘発します
- アルギニン・ヴァソプレシンは 横隔膜のCA2シナプス伝達を促進することで 攻撃性を高めます
結論:
- ヒポカンパのCA2は 横隔膜回路が社会的攻撃に 欠かせない
- アルギニン・バソプレシンが この回路を調節し 内的な状態と 動機づけられた行動を結びつけます
- このメカニズムは 社会的記憶と攻撃を統合し 内的な状態によって制御されます
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