生存支援の豚心臓異種移植に一貫した成功
Matthias Längin1,2, Tanja Mayr1,2, Bruno Reichart3
1Department of Anaesthesiology, University Hospital, LMU Munich, Munich, Germany.
Nature
|December 7, 2018
まとめ
免疫の拒絶を軽減し 命を支えるために遺伝子組み換えられた豚の心臓は 心臓移植を必要とする患者にとって 有望な代替手段です この研究により,バビオンの長期的な機能が達成され,臨床的な異種移植に向けた重要なステップとなりました.
科学分野:
- 心血管外科
- 移植免疫学
- 異種移植の研究
背景:
- 末期性心不全の心臓移植を制限する.
- 豚から霊長類への異種移植は 潜在的な解決策として検討されています
- 以前の異種移植では 長期的な生存と機能が限られていた.
研究 の 目的:
- バビオンの遺伝子組み換え豚心臓の長期的オートトープ機能を評価する.
- 特定の保存と移植後の管理が異種移植の生存性を保証するかどうかを判断する.
- 臨床的な心臓異種移植のための臨床前モデルを進める.
主な方法:
- 遺伝子組み換え多種豚心臓 (α1,3-ギャラクソシルトランスフェラーゼノックアウト,ヒトのCD46とトロンボモジュリンを発現する) を利用した.
- 絶え間ない perfusion で非血栓保存を使用しています.
- バビオンの移植後の制御された成長管理を実施した.
主要な成果:
- 異種移植された豚の心臓で 195日までの持続的な生命維持機能を達成した.
- 長期のオートトープ機能が示され,以前の生存制限を克服した.
- 心臓異種移植の生存可能性を評価するための厳格な臨床前モデルを確立した.
結論:
- 遺伝子組み換え豚の心臓は 特定の保存と管理によって バビオンの長期的正体機能を達成できます
- これは臨床的な心臓異種移植への重要なマイルストーンです.
- 異種移植が臓器不足の危機を 解決する可能性を裏付けています
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