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In Silico Clinical Trials for Cardiovascular Disease
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非症状性動脈硬化症の視覚化による最適心血管疾患予防 (VIPVIZA): 実用的な,オープンラベル,ランダム化制御試験
Ulf Näslund1, Nawi Ng2, Anna Lundgren2
1Heart Centre and Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
Lancet (London, England)
|December 8, 2018
まとめ
亜臨床性動脈硬化に関する画像超音波の情報は,フレミングハムリスクスコアを低下させることで,心血管疾患の予防を改善しました. この視覚的補助器は ライフスタイルの変更や薬の服用を促し, 予防の重要な課題に取り組んでいます
科学分野:
- 心臓病科
- 予防 医療
- 医療用イメージング
背景:
- 心血管疾患 (CVD) の原発予防は,ガイドラインの遵守が不十分であるため,困難です.
- サブクリニック性動脈硬化症,特に動脈動脈硬化症は,主要な予防のターゲットです.
- 心血管疾患の予防に 患者と医師の関与を向上させるには 新しい戦略が必要です
研究 の 目的:
- 副臨床的動脈動脈硬化に関する超音波ベースの画像情報が心血管疾患の予防を改善するかどうかを評価する.
- 医療従事者や個人に対する この介入の影響を評価する.
- 確立されたCVDリスクスコアへの影響を決定する.
主な方法:
- 人口ベースの予防プログラムに統合された実用的でオープンなランダム化制御試験 (VIPVIZA).
- 参加者 (40歳,50歳,60歳,リスク因子) は標準的な治療を受けたり,画像による頸動脈超音波検査の結果と看護師のカウンセリングを受けたりしました.
- 1年間の追跡調査でFraminghamリスクスコア (FRS) と欧州のシステマティック冠動脈リスク評価 (SCORE) の変化が主なアウトカムであった.
主要な成果:
- FRSとSCOREの有意な差異は1年後にグループごとに観察された.
- 介入グループはFRSの減少を示したが,対照群は増加を示した.
- SCOREは両方のグループで増加したが,介入グループでは著しく減少した.
結論:
- 亜臨床性動脈硬化症の画像表現は,心血管疾患の予防に寄与する.
- この視覚的フィードバックの方法は 薬の服用やライフスタイルの変化を 改善する可能性を 示しています
- 心血管疾患の予防における低粘着性に対抗するために,そのような方法のさらなる開発は正当化されています.
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