CD30陽性外周T細胞リンパ腫 (ECHELON-2) に対する化学療法とブレントキシマブベドチン: 全球,ダブルブラインド,ランダム化,第3相試験
Steven Horwitz1, Owen A O'Connor2, Barbara Pro3
1Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Lancet (London, England)
|December 8, 2018
まとめ
標準のCHOP化学療法と比較して,ブレンツシマブベドチン,サイクロフォスファミド,ドクソルビシン,プレドニゾーン (A+CHP) は,CD30陽性外周T細胞リンパ腫の患者に進行性のない生存期間を有意に改善しました. この新しい治療法は 管理可能な安全性プロファイルを持つ優れた治療法です
科学分野:
- 血液学
- 腫瘍学
- 臨床試験
背景:
- CD30陽性外周T細胞リンパ腫 (PTCL) は攻撃的なノンホッジキンリンパ腫です.
- 以前の研究では,PTCLにおけるブレンツシマブベドチンの有望な作用が示された.
研究 の 目的:
- 以前治療を受けていないCD30陽性PTCL患者におけるA+CHPとCHOPの有効性と安全性の比較.
- 主要エンドポイントとして,不発症生存率 (PFS) を評価する.
主な方法:
- ECHELON-2は第3相,ダブルブラインド,ランダム化,プラセボ対照試験でした.
- 未治療のCD30陽性PTCL患者452人をランダムにA+CHPまたはCHOPに6~8サイクルに分けました.
- ヒストロジカルサブタイプとIPIスコアによる分層化が行われました.
主要な成果:
- CHOP (20. 8ヶ月) と比較すると,PFSの中央値はA+CHPで有意に長かった (HR 0. 71,p=0. 0110)
- 発熱性ニュートロペニアと周辺神経症を含む有害事象は,グループごとに類似していました.
- 致命的な有害事象は両腕で低かった (3% A+CHP 対 4% CHOP).
結論:
- 前線A+CHPは,CD30陽性PTCLにおいて,CHOPよりも優れた有効性を示しています.
- A+CHPは,管理可能な安全性プロファイルで,改善されたPFSと全生存率を提供します.
- ブレンツシマブ・ベドチンを含む治療法は,この患者群の治療における新しい標準です.
関連する概念動画
01:30Introduction to Global Positioning System
516
The Global Positioning System (GPS) revolutionized positioning on Earth, providing precise location data through satellite ranging. The GPS system was developed in 1978 by the U.S. Department of Defense for military use, and it became available for civilian applications in 1983, transforming fields including navigation, fleet management, and time synchronization for telecommunications systems.GPS consists of satellites in medium Earth orbit, about 20,200 kilometers above the surface,...
516
01:26Errors in Global Positioning System
354
Global Positioning System (GPS) technology has revolutionized navigation and positioning, but its accuracy is often compromised by various errors. These errors, stemming from environmental, satellite, and receiver-related factors, require careful mitigation to ensure reliable performance across applications.Atmospheric ErrorsGPS signals travel through the Earth’s ionosphere and troposphere, introducing delays which affect accuracy. The ionosphere is strongly influenced by charged particles,...
354
02:07Blind Procedures
13.4K
Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which...
13.4K
01:28Field Application of Global Positioning System
328
The Global Positioning System (GPS) has become an indispensable tool in fieldwork, offering unparalleled precision and efficiency for surveying, navigation, and infrastructure development. By harnessing signals from a constellation of satellites, GPS receivers determine the location of objects with remarkable speed and accuracy, often completing calculations within a second.Advantages of Modern GPS TechnologyContemporary GPS receivers are designed to meet the practical demands of field...
328
01:30Types of Global Positioning System Surveys
368
GPS surveying methods vary in application, accuracy, and data collection techniques, catering to diverse surveying and mapping needs. Static GPS, kinematic GPS, and real-time kinematic (RTK) surveying are widely used. Each technique offers distinct advantages.Static GPS involves placing one receiver at a known reference point and another at the target point. It collects exact positional data by observing multiple satellite ranges over an extended period, achieving centimeter-level accuracy for...
368
01:27Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists
673
5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
673