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A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9
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スタチンの治療と比較してPCSK9の遺伝的阻害による代謝的影響

Eeva Sliz1,2, Johannes Kettunen1,2,3, Michael V Holmes4,5,6,7

  • 1Center for Life Course Health Research, University of Oulu, Oulu, Finland.

Circulation
|December 8, 2018
PubMed
まとめ

PCSK9阻害剤とスタチンは,同様の代謝効果がありますが,PCSK9阻害剤はVLDL脂質に弱い効果を持ち,潜在的に心血管リスクの減少につながる可能性があります.

キーワード:
メンデルのランダム化PCSK9 について脂質と脂質タンパク質の代謝メタボロミクススタチン療法

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