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Epigenetic Regulation01:46

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Counting is the type of measurement that is free from uncertainty, provided the number of objects being counted does not change during the process. Such measurements result in exact numbers. By counting the eggs in a carton, for instance, one can determine exactly how many eggs are there in the carton. Similarly, the numbers of defined quantities are also exact. For example, 1 foot is exactly 12 inches, 1 inch is exactly 2.54 centimeters, and 1 gram is exactly 0.001 kilograms. Quantities...
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合成読み書きモジュールを用いたエピジェネティック制御工学

Minhee Park1, Nikit Patel1, Albert J Keung2

  • 1Biological Design Center, Boston University, Boston, MA 02215, USA; Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA.

Cell
|December 12, 2018
PubMed
まとめ
この要約は機械生成です。

科学者たちは,N6-メチラデニン (m6A) のDNA改変を用いて哺乳類の細胞で新しい表遺伝子制御システムを開発した. このシステムはエピジェネティック・メモリを プログラムし維持し,エピジェネティック・レギュレーションを 研究するための新しいツールキットを 提供します

キーワード:
DNAメチル化N6-メチラデニン細胞工学クロマチンエピジェネティック・メモリーエピジェネティクス遺伝子調節読み書き合成生物学

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科学分野:

  • エピジェネティクスと遺伝子調節
  • 合成生物学
  • 哺乳類の細胞生物学

背景:

  • DNAとヒストンの化学的変異は 細胞の分化における表遺伝的プログラムを編成する.
  • 染色体マークの書き手と読者の 規制ネットワークが これらの表遺伝子プログラムを支配しています

研究 の 目的:

  • N6-メチラデニン (m6A) を使用して哺乳類の細胞で正方形の表遺伝子制御システムを確立する.
  • 細胞状態のプログラム化のための合成"読み書き"エピジェネティックアーキテクチャの可能性を調査する.

主な方法:

  • m6A DNAの改変を記述し読み取るための合成因子の開発
  • m6A依存の転写状態を誘導し,広めるための最小限の規制回路の構築.
  • エピジェネティック継承とクロマチン拡散のダイナミクスを理解するために 数学モデルを使用します

主要な成果:

  • 哺乳類の細胞で機能的なm6Aベースの表遺伝子制御システムを確立しました.
  • 合成回路が新生代機能を プログラムする能力を示した
  • エピジェネティックメモリの空間的伝播と維持が 誘発されたトランスクリプション状態で示されました

結論:

  • プログラム可能な遺伝子調節のための概念的に検証された"読み書き"エピジェネティックアーキテクチャ.
  • エピジェネティック調節モデルとエピジェネティック情報のエンコーディングを調査するための新しいツールキットを提供しました.
  • 細胞生物学と合成生物学を進めるための合成表遺伝子学の可能性を強調した.