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クリオ-EMによるネイティブレンズコネクシン46/50の細胞間経路の構造

Janette B Myers1, Bassam G Haddad1, Susan E O'Neill1

  • 1Department of Chemistry, Portland State University, Portland, OR, USA.

Nature
|December 14, 2018
PubMed
まとめ

研究者は冷凍EMを用いてレンズギャップ・ジャンクション・チャネル (Cx46/50) を研究し,遺伝性白内障に関する構造的な洞察を明らかにした. この研究は,コネクシン共組がチャネル機能と疾患メカニズムにどのように影響するかを明らかにしています.

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